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:: Volume 9, Issue 1 (Spring 2018) ::
jiitm 2018, 9(1): 37-45 Back to browse issues page
The effect of hydroalcoholic extract of Cyperus rotundus rhizome on memory and learning in Streptozotocin-induced rat model of Alzheimer's disease
S. Nasri *, M. Naseri, M. Piri, F. Mahmoudinia
Abstract:   (3904 Views)
               
Background and Purpose: Alzheimer’s disease is one of the most important neurodegenerative diseases resulting in free radicals and oxidative stress production. Since Cyperus rotundus plant contains anti-oxidant components, the effects of Cyperus rotundus tuber hydroalcoholic extract on learning and memory improvement in the Alzheimer model rats was investigated. 
Methods and Materials: In this experimental research, Intracerebroventricular streptozotocin injection in the rats created a suitable model of Alzheimer. Rats were divided into 7 groups: control, sham, Alzheimer, Alzheimer + extract treated, and normal + extract treated groups. Treated groups received the extract with dosages of 100 and 200 mg/kg in 21 days. The rate of rat's learning and spatial memory was investigated using passive avoidance learning and Y-maze methods.
Results: In the rate of IL (Initial Latency), there was no difference between groups (p>0.001). There is a different meaning in the rate of STL (Step through Latency) between different groups (p<0.001). Considering the Y-maze examination, there was no significant difference between the groups (p>0.001).
Conclusion: Results of STZ injection showed significant decrease in memory and learning. Treatment with Cyperus rotundus extract could increase the capability of consolidation and recall.
Keywords: Alzheimer, Streptozotocin, Cyperusrotundus, Memory and Learning, Shuttle box, Y-maze
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Type of Study: Origianal Research | Subject: Special
Received: 2017/05/31 | Accepted: 2018/02/16
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Nasri S, Naseri M, Piri M, Mahmoudinia F. The effect of hydroalcoholic extract of Cyperus rotundus rhizome on memory and learning in Streptozotocin-induced rat model of Alzheimer's disease. jiitm. 2018; 9 (1) :37-45
URL: http://jiitm.ir/article-1-959-en.html


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Volume 9, Issue 1 (Spring 2018) Back to browse issues page
مجله طب سنتی اسلام و ایران Journal of Islamic and Iranian Traditional Medicine

Creative Commons License
This Journal is licensed under a Attribution-NonCommercial 4.0 International License

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