Background and Purpose: Skin color and its changes which can be as a sign of many skin disorders may be as a significant assessment for dermatologic studies. This may be influenced by internal and external factors‚ of course the internal factors are not mentioned enough. These conditions and their treatment considering the basic etiology have been consulted by traditional Persian medicine philosophers.

Methods and Materials: This article is a product of a library study in the main references of Traditional Persian Medicine texts and related articles using related key words about the etiology of skin discoloration and the ways for its treatment.

Conclusion: The etiology of skin discoloration and its therapeutic methods have been discussed very well by Traditional Persian Medicine philosophers‚ whereas the common medicine approach is mostly bowed to topical agents‚ which have only temporary effects and also may make it worse. So recognition this perspective in Traditional Persian Medicine can help us to consider a most effective treatment for this problem.