[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 9, Issue 1 (Spring 2018) ::
jiitm 2018, 9(1): 5-11 Back to browse issues page
Acetylcholinesterase inhibitory activity of fixed and essential oil of laurus nobolis L. fruit
A.M Ranjbar *, N Hajimohammadi, A.R Moradi, H. Nadri, V. Ramezani, A. Mosadegh
Abstract:   (4617 Views)
Background and Purpose: Alzheimer's disease (AD) is a neurodegenerative disorder which is an ordinary type of dementia in the elderly. It impairs memory and cognitive ability. Different kinds of treatment have been presented to cure AD or reduce its progression, most of which are based on inhibition of acetylcholinesterase enzyme. According to traditional Persian medicine, the bay laurel fruit has been applied for different medical purposes such as improving mind and memory function. The aim of the presented study was to evaluate the acetylcholinesterase inhibitory activity of fixed and essential oil of Laurus nobilis L. fruit.
Methods and Materials: Dried fruit of Laurus nobilis L. was subjected to hydro distillation for obtaining the essential oil, then the fixed oil of fruit was extracted by a Soxhlet apparatus (n-hexane as a solvent). Ellman method was employed to evaluate the acetylcholinesterase inhibitory activity of bay laurel fruit.
Results: Both fixed and essential oil exhibited acetylcholinesterase inhibitory activity which the percentage of inhibition for fixed oil (1.35 mg.mL-1) and essential oil (1.8 μg.mL-1) was 34.33 ±2.4 and 50, respectively.
Conclusion: According to the results obtained from the present study, the effect of bay laurel on mind and memory can be relevant to its acetylcholinesterase inhibitory activity.
Full-Text [PDF 52 kb]      
Memorial article: Origianal Research | Subject: Special
Received: 2018/03/1 | Accepted: 2018/04/5
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ranjbar A, Hajimohammadi N, Moradi A, Nadri H, Ramezani V, Mosadegh A. Acetylcholinesterase inhibitory activity of fixed and essential oil of laurus nobolis L. fruit. jiitm 2018; 9 (1) :5-11
URL: http://jiitm.ir/article-1-956-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 9, Issue 1 (Spring 2018) Back to browse issues page
مجله طب سنتی اسلام و ایران Journal of Islamic and Iranian Traditional Medicine

Creative Commons License
This Journal is licensed under a Attribution-NonCommercial 4.0 International License

Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 4509