The book “Tohfe- al- Momenin” is a comprehensive pharmacopeia of singular and compound drugs, written by a great Iranian physician and pharmacist, Seyed Mohammad Momen Tonekaboni in 1080 according to Islamic lunar calendar. A lot of manuscripts, numerous copies, and translation into Arabic and Turkish languages which took place shortly after its publication imply its importance. This book is still most valuable among the followers of traditional medicine. Besides quotation of remarks from previous works, the author adds his own experiences and innovations. In this article, we tried to address some experiences and innovations implied in “Tohfe- al- Momenin”.