Introduction: Persian cultural texts and Iranian poets’ novels and poetries are our great scientific and cultural treasures that are inheritances incorruptible and undefiled. It can be a great backing for our scientific progress and development . Researches about these treasures ,protect us from the lack of historical and cultural recognition of ourselves and it can be a good motivation for establishing the basis of a civilization  that Iranians had 1000 years ago and the impression of this civilization is seen in the beyond of history and all sciences. Now the main questions are:Have diseases and their common remedies been explained in literary sources which are the mirror of their time?and how is the relationship between literary sources and medicine?

 Aim: This article explains those medical idioms which are used not only in diseases but also in the ways of remedies in Kharazmshahi,s book and these idioms have been reflected in the poems of Molavi.

Methodology: in this research,it has been suggested some diseases such as smallpox, ascites, cardinal humors, intermittent fever, hotness, frisson, delirium, cholera, recurrence of disease and remedies such as antidote, collyrium, venesection and bloodlet. The purpose is making acquainted with diseases and common traditional remedies in the period of Molavi. To answer these questions and the confirmation of these subjects which are very important in Masnavi, we have used the analytical-descriptive method and all contexts and information in this research have been analyzied.