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Showing 2 results for Streptozotocin
S. Romina, M. Norozi,
Volume 8, Issue 3 (12-2017)
Abstract
Background and Purpose: Since diabetes is the most common endocrine disorder, and its growing trend has raised concerns in the healthcare system, the use of medicinal herbs may be effective in treating diabetes alone or in combination with chemical drugs. Therefore, the aim of this study was to investigate the effect of Nasturtium officinal extract on blood glucose in diabetic rats.
Methods and Materials: In this experimental study, 40 male mice with an average weight of 25-20 Grams after sustainability in standard animal house were divided randomly into 5 groups of 8 animals. Four drug groups by intraperitoneal injection of STZ (Streptozotocin) to the extent 60mg / kg and a non-diabetic control group were considered. Blood sugar was analyzed before and at 24, 72 hours and one week after injection of STZ and administration of hydroalcoholic Watercress extract. The first three groups received Watercress extract with three different doses (100, 300, 600 mg/kg). Data was analyzed using SPSS v.16 software. Paired t-test was used for statistical analysis.
Results: Blood sugar of groups treated with different doses of NF (Watercress) at 24 and 72 hours and a week after was significantly lower than the control group at the same time (p<0.05) so that blood sugar groups extract-treated diabetic, took 72 hours to 24 hours compared to 72 hours in one week showed a greater reduction (p<0.05) greater drop in blood glucose concentration 300 mg/kg respectively.
S. Nasri, M. Naseri, M. Piri , F. Mahmoudinia,
Volume 9, Issue 1 (6-2018)
Abstract
Background and Purpose: Alzheimer’s disease is one of the most important neurodegenerative diseases resulting in free radicals and oxidative stress production. Since Cyperus rotundus plant contains anti-oxidant components, the effects of Cyperus rotundus tuber hydroalcoholic extract on learning and memory improvement in the Alzheimer model rats was investigated.
Methods and Materials: In this experimental research, Intracerebroventricular streptozotocin injection in the rats created a suitable model of Alzheimer. Rats were divided into 7 groups: control, sham, Alzheimer, Alzheimer + extract treated, and normal + extract treated groups. Treated groups received the extract with dosages of 100 and 200 mg/kg in 21 days. The rate of rat's learning and spatial memory was investigated using passive avoidance learning and Y-maze methods.
Results: In the rate of IL (Initial Latency), there was no difference between groups (p>0.001). There is a different meaning in the rate of STL (Step through Latency) between different groups (p<0.001). Considering the Y-maze examination, there was no significant difference between the groups (p>0.001).
Conclusion: Results of STZ injection showed significant decrease in memory and learning. Treatment with Cyperus rotundus extract could increase the capability of consolidation and recall.
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