Nowadays, traditional medicine and ethnobotany are the two important issues that have attracted interest in many countries. Traditional medicine deals with past studies and experience and ethnobotany relates to the native botany of a region. In recent years, these topics have received particular importance in many countries, including European countries. Considering the scarcity of information on effects of medicinal plants, traditional medicine and ethnobotany can play an important role in discovering the unknowns. Considering the various geographical conditions in our country, different ecosystems and flora exist in Iran. As there is growing need in today's world for new herbal drugs and considering the industrialization of this sector, we should pay more attention to the herbal sources of the country from this viewpoint. In the current study, the plants of some parts of Kashan were collected, systematically identified, and studied in two consecutive years. Furthermore, the traditional uses of these plants were recorded through interviewing local people. These plants were mostly used in the treatment of gastrointestinal and respiratory diseases by local people. It was shown that most plants grow in the area were medicinal. Therefore, further evaluation of the plants is recommended.