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Showing 2 results for Mohammadia
E. Mohammadia, M. Doostmohammadib, S. Gavanji, , H. Baghshahi, Z. Golestan Nejad, . Bakhtari, M. R. Golestan Nejad, A. Moatamedi,
Volume 8, Issue 3 (Fall 2017)
Abstract
Background and Purpose: Nowadays cancer is becoming a global health problem. Honey bee venom has been used for thousands of years in treating different diseases. Recently its uses as an anti-cancer compound attracted scientist’s attention. Determining the main components of bee venom which induce apoptosis can result in finding new anti-cancer compounds. Bee venom is a complex mixture of peptides, enzymes and biologically active amines like melittin and phospholipase A2.
Methods and Materials: This study was an experimental study. The cancer column cells (HT-29) and mice fibroblast cells (L929) were cultured in RPMI-1640 medium. Cells were treated with different concentrations of honey bee venom (0.1-12 µg/ml) in three times of 24, 48 and 72 hours. After this period the percent of living cells was determined through MTT assay. The analysis of data was done with SPSS software using One Way ANOVA method. Also, two cell lines were analyzed in the same concentrations of bee venom using the T-test. Results: in concentration 0.6 µg/ml and time 24 h the number of living cells reduced and in concentration 6 µg/ml all cells died. In concentration 2 µg/ml significant inhibitory effect on L929 was seen and in concentration 12 µg/ml and time 12 hours all cells died. Honey bee venom had an inhibitory effect on human colon cancer cells (HT-29) in vitro.
Conclusion: Honey bee venom cytotoxicity effect on human colon cancer cells (HT-29) was demonstrated. It seems that the induction of apoptosis in cancer cells treated with this compound is the cause of cell death which should be more investigated in the future.
Koroush Ghanadi, Mehdi Mohammadian Amiri, Aliasghar Manouchehri, Mohammad Darvishi, Neda Dastyar, Mahdeyeh Ahmadi, Saber Abbaszadeh,
Volume 14, Issue 1 (spring 2023)
Abstract
Background and Purpose: Fatty liver disease (NAFLD) is a condition in which triglyceride accumulates in liver cells of a person without a history of alcohol consumption, and is considered one of the main causes of cryptogenic cirrhosis and chronic liver disease. Currently, there is no treatment other than lifestyle changes. In spite of the progress in synthetic drugs, antioxidant therapy and the use of herbal medicines can help improve steatosis and inflammation to a great extent due to their availability. Therefore, herbal medicines seem very attractive for the effective management of this disease. Due to the high prevalence of this disease, the present study has been designed to investigate and report non-alcoholic fatty liver treatments.
Materials and Methods: In this review study, English and Persian articles were searched with keywords such as liver, herbal medicines, non-alcoholic fatty liver, antioxidant with Boolean operators including AND and OR from January 2016 to the end of February 2021. Published articles were searched in the scientific databases including Cochrane, PubMed, Scopus, ScienceDirect, Embase and SID. Thirty-six articles were initially obtained. Nine articles were excluded due to the lack of relevance to the subject and results, and finally 27 articles were included in the study.
Results: Based on the results of this study, it was found that medicinal plants play a role in improving non-alcoholic fatty liver disease through several mechanisms such as increasing the metabolism of fats, increasing the synthesis of bile acids, and reducing oxidative stress and inflammation.
Conclusion: Plant polyphenols and antioxidants can be used as medicine to prevent liver steatosis due to their antioxidant properties, as well as therapeutic and protective effects. The results of the present study show that possessing multiple biochemical mechanisms, natural compounds have the ability to affect the pathogenesis of non-alcoholic fatty liver disease. Thus, conducting further studies is recommended.
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