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Multiple sclerosis and temperament (Mizaj): A case-control study in southeast of Iran
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Mahlagha Dehghan   , Fatemeh Ghaedi-Heidari * , Mohammad Mazaheri |
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Abstract: (168 Views) |
Background and Purpose: Based on Persian Medicine (PM), all creatures and every human have a specific temperament (Mizaj). Temperament results from an interaction of four qualities of hotness, coldness, wetness, and dryness. These qualities are created by four elements of fire, water, air, and earth. Based on the combination of the elements, every individual has their own unique temperament. In PM, it is believed that temperament plays an important role in physiologic changes, health level, and susceptibility to different diseases. Therefore, the aim of this study was to determine the correlation between temperament (body Mizaj) and the risk of developing Multiple Sclerosis (MS).
Materials and Methods: This is a case-control study conducted on 160 patients with MS and 480 healthy individuals in Kerman. Data were gathered by a three-part researcher-conducted questionnaire including personal information, some environmental factors, and Mojahedi's Mizaj questionnaire. Data were analyzed using SPSS version 18 with descriptive and inferential statistics (χ2, univariate and multivariate logistic regression).
Results: Individuals with a "cold and wet" temperament exhibited a lower risk of developing MS compared to those with a balanced temperament (the cold temperament: OR=0.24 (95% CI: 0.08–0.75), and the wet temperament: OR= 0.38 (95% CI: 0.20–0.71). Also, multivariate logistic regression test revealed “cold & moderate” as well as “moderate & wet” temperaments as significant protective factors against developing MS.
Conclusion: The study indicated that the “cold & moderate” and “moderate & wet” temperaments are protective factors against MS, but such results are preliminary and their mechanisms could not be supported by the traditional literature. Therefore, it is suggested that future studies be conducted with more accurate methodological methods such as cohort studies to justify temperamental changes in patients with MS. |
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| Keywords: Multiple Sclerosis, Persian Medicine, Temperament |
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Full-Text [PDF 980 kb]
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Memorial article: Origianal Research |
Subject:
Special
Received: 2025/05/11 | Accepted: 2025/05/27
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