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In the Traditional Iranian Medicine (TIM), 36 different drug formulations have been mentioned. Each of these formulations is used for specific diseases, and deliberate points should be followed in their development. In the present paper, one of the most important drug formulations in the TIM, etrifal, is described. Firstly, according to recent studies, the antioxidant, anti-arthritis, anti-cancer, and ant-bacterial effects, as well as the pharmaceutical studies on the formulation have been mentioned. Then, viewpoint of the TIM toward atrifel and some major forms of etrifal, its properties, the formulation temperament, dosage, effect, and duration of action were considered according to major books on drug formulations in the TIM. These books were called Qarabadin. Finally, the phytochemical evaluation of etrifal-e saghir prepared according to the TIM sources is addressed.