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The effect of hydroalcoholic extract of Cyperus rotundus rhizome on memory and learning in Streptozotocin-induced rat model of Alzheimer's disease
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S. Nasri *   , M. Naseri , M. Piri , F. Mahmoudinia |
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Abstract: (4660 Views) |
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Background and Purpose: Alzheimer’s disease is one of the most important neurodegenerative diseases resulting in free radicals and oxidative stress production. Since Cyperus rotundus plant contains anti-oxidant components, the effects of Cyperus rotundus tuber hydroalcoholic extract on learning and memory improvement in the Alzheimer model rats was investigated.
Methods and Materials: In this experimental research, Intracerebroventricular streptozotocin injection in the rats created a suitable model of Alzheimer. Rats were divided into 7 groups: control, sham, Alzheimer, Alzheimer + extract treated, and normal + extract treated groups. Treated groups received the extract with dosages of 100 and 200 mg/kg in 21 days. The rate of rat's learning and spatial memory was investigated using passive avoidance learning and Y-maze methods.
Results: In the rate of IL (Initial Latency), there was no difference between groups (p>0.001). There is a different meaning in the rate of STL (Step through Latency) between different groups (p<0.001). Considering the Y-maze examination, there was no significant difference between the groups (p>0.001).
Conclusion: Results of STZ injection showed significant decrease in memory and learning. Treatment with Cyperus rotundus extract could increase the capability of consolidation and recall. |
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| Keywords: Alzheimer, Streptozotocin, Cyperusrotundus, Memory and Learning, Shuttle box, Y-maze |
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Full-Text [PDF 50 kb]
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Memorial article: Origianal Research |
Subject:
Special
Received: 2017/05/31 | Accepted: 2018/02/16
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