TY - JOUR JF - jiitm JO - jiitm VL - 9 IS - 1 PY - 2018 Y1 - 2018/6/01 TI - The effect of hydroalcoholic extract of Cyperus rotundus rhizome on memory and learning in Streptozotocin-induced rat model of Alzheimer's disease TT - بررسی تأثیر عصارۀ هیدروالکلی ریزوم گیاه سُعد کوفی بر حافظه و یادگیری در رت‌های نر آلزایمری شده با استرپتوزوتوسین N2 - Background and Purpose: Alzheimer’s disease is one of the most important neurodegenerative diseases resulting in free radicals and oxidative stress production. Since Cyperus rotundus plant contains anti-oxidant components, the effects of Cyperus rotundus tuber hydroalcoholic extract on learning and memory improvement in the Alzheimer model rats was investigated. Methods and Materials: In this experimental research, Intracerebroventricular streptozotocin injection in the rats created a suitable model of Alzheimer. Rats were divided into 7 groups: control, sham, Alzheimer, Alzheimer + extract treated, and normal + extract treated groups. Treated groups received the extract with dosages of 100 and 200 mg/kg in 21 days. The rate of rat's learning and spatial memory was investigated using passive avoidance learning and Y-maze methods. Results: In the rate of IL (Initial Latency), there was no difference between groups (p>0.001). There is a different meaning in the rate of STL (Step through Latency) between different groups (p<0.001). Considering the Y-maze examination, there was no significant difference between the groups (p>0.001). Conclusion: Results of STZ injection showed significant decrease in memory and learning. Treatment with Cyperus rotundus extract could increase the capability of consolidation and recall. SP - 37 EP - 45 AU - Nasri, S. AU - Naseri, M. AU - Piri, M. AU - Mahmoudinia, F. AD - KW - Alzheimer KW - Streptozotocin KW - Cyperusrotundus KW - Memory and Learning KW - Shuttle box KW - Y-maze UR - http://jiitm.ir/article-1-959-en.html ER -