Background and Purpose: Iranian Traditional Medicine is a scientific school in the field of diagnosis and treatment has a long history. Obstructive disease and opener “Mofatteh” medications have a special place in Iranian traditional medicine. Scientists of traditional medicine had known the use of natural remedies with the mechanism of action and about treatment of obstructive diseases have provided different solutions. So according to the high prevalence obstructive disease (especially coronary artery and brain disease) in mortality and years of life lost, we decided to review the Iranian medical books and use from their opinions about Mofatteh drugs and their mechanisms.

Materials and Methods: This study is an explanation review, after searching the original sources of traditional medicine, we extracted the “Mofateh” agents and  based on the consensus and emphasis philosophers about opening of  “Mofateh” drugs, every drugs have been given a point.

Results: The results of this study showed that the opening process, has directly proportional to the materia nature, especially the hot temperament.