Introduction: From the viewpoint of traditional Iranian medicine, spleen is the supply of black bile and it has an important role to make strength of body and limbs and patience of people via healthy black bile. So spleen can has major role in many diseases.

Methods: In this paper all the symptoms of spleen diseases are accumulated from ten textbooks of Traditional Iranian Medicine and analyzed.

Results: 119 symptoms are accumulated. These are mainly including symptoms such as body color, gastrointestinal symptoms, and pulse or urine changes, psychiatric symptoms and so on. Among these symptoms 21 items have more frequency like diarrhea, anorexia and bloating.

Discussion: Some of the symptoms are more frequent and In general considering to the function of spleen in immune system, removal of old red blood cells, appetite disorders, also its relation to liver , stomach, intestine, crises, skin pigmentation and insomnia, help us to better diagnose and treat the diseases which are correspond to the organs or conditions mentioned above.