Skin disease is one of the important parts of Iranian Traditional Medicine .There are multiple and no expensive therapies for each of them. one of the most popular skin disease in Iranian Traditional Medicine named Kalaf which is a skin hyper pigmentation of the face .It is caused by different factors such as pregnancy, menstrual disorders, gastric disease, hepatic failure and… .On the other hand etiologies and clinical manifestations of Melasma are very similar to Kalaf disease. Based on the fact that Melasma treatment is not so effective and also has many complications, the main goal of this systematic review is to study Iranian Traditional Medicine books and make a comparison between Melasma and Kalaf in order to find their similarities. So if they were the same in general, on the next step we can use simple and easy and more effective remedies of Kalaf disease in treatment of Melasma patients.